MyBioSource.com's Rabbit anti CD3 zeta Polyclonal antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Radioimmunoassay, and Western Blot. The Rabbit anti CD3 zeta Polyclonal antibody was generated using CD247, CD3 zeta, CD3-eta, CD3Q, and TCR zeta chain as the antigen and it reacts with Human, Mouse, Rat, and Zebrafish/Fish.
Description
CD3 is a glycoprotein consisting of up to five polypeptide chains (gp20, gp26, p16, p20, p28). It forms three dimmers: a heterodimer of gamma and epsilon chain, a heterodimer of delta and epsilon chains and a homodimer of two zeta chains or a heterodimer of zeta and eta chains. CD3 is required for proper assembly, trafficking and surface expression of TCR complex. CD3 is expressed by Thymocytes in a developmentally regulated manner and by all mature T cells. CD3 is involved in T cell activation, proliferation and apoptosis pathway. This protein is present on virtually all peripheral blood T cells and Thymocytes. The CD3 zeta plays an important role in coupling antigen recognition to several intracellular signal transduction pathway. Low expression of the antigen results in impaired immune response